Is It Serious with Proteinuria 1+ and Diabetes

2019-03-02 17:54

Question: I have diabetes. Recently urine test report showed that protein in urine was 1+. Is it serious?

Is It Serious with Proteinuria 1+ and DiabetesAnswer: The total amount of 24-hour urinary protein in normal adults is less than 150 mg, and that in adolescents is slightly higher than 300 mg/24h. When the total amount of urinary protein exceeds 300 mg/24h, it is called proteinuria. This is a common clinical manifestation of Diabetic Nephropathy and other kidney diseases.

Proteinuria is the most troublesome problem in patients with diabetic nephropathy. The amount of proteinuria is not only related to the degree of kidney damage, but also one of the main indicators to consider the progress of diabetic nephropathy.

Normal human urine contains very small amounts of protein, and routine examination of urine protein is negative.

However, if the glomerular function changes due to renal lesions, resulting in increased permeability of glomerular filtration membranes, the protein in glomerular filtrate can be increased, which exceeds the renal tubular reabsorption capacity, and albuminuria will occur. Therefore, importance should be attached to the proteinuria.

Treatment for Diabetic Nephropathy with proteinuria

Reducing diabetic proteinuria can reduce its continued damage to the kidney. But it can't change the pattern of kidney damage. So once encountering cold, fatigue and other susceptible factors, diabetic proteinuria patients will still have proteinuria. So we should focus on the treatment of damaged nephrons at this time.

There are three different types of nephrons in patients with diabetic nephropathy: viable nephron, pathological nephron and necrotic nephron. From surviving nephron to pathological nephron to necrotic nephron is the process of continuous development of renal fibrosis to scar formation. Diabetic proteinuria patients are at the stage of fibrosis. At this time, the key point of treatment is to improve renal microcirculation, alleviate ischemia and hypoxia, increase the supply of residual nephron, increase the metabolism of damaged nephron, and prevent the formation of microthrombosis. At the same time, it can also effectively alleviate the three high states of glomerulus (high perfusion, high filtration, and high internal pressure), reduce protein leakage, promote detoxification, block the fibrosis process, prevent the formation of nephron scar and reverse renal function. When kidney function gets improved, proteinuria will turn negative.

When protein presents in urine for diabetic patients, importance should be attached, because it may mean kidneys are damaged. For more information on Diabetic Nephropathy treatment, please leave a message below or contact online doctor.

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