4 Kinds of Drugs Can Stabilize Proteinuria for A Long Time

2018-08-22 16:02

4 Kinds of Drugs Can Stabilize Proteinuria for A Long Time4 kinds of drugs can stabilize proteinuria for a long time, among which 3 kinds can protect renal function, so it is unnecessary to worry about the deterioration of kidney disease.

The presence of proteinuria can be a "time bomb" for kidney function, and can be a serious threat, especially when proteinuria occurs repeatedly. Therefore, in the treatment of early stage kidney disease, proteinuria should be attached importance. And early drug use is of great significance for reducing proteinuria and protecting renal function.

Although some kidney patients are treated in time and they keep on taking the drug, the effect on reducing proteinuria is not very good, which has a direct impact on renal function. These 4 kinds of anti-proteinuria drugs, 3 of which have the effect of protecting the kidneys. Are you using them?

Reducing steroid-dependence, safe and effective — Rituximab

This drug has been used in 5 types of kidney disease: primary Membranous Nephropathy; Primary Nephrotic Syndrome with steroid dependence or resistance (pathological type is Minimal Change Disease, FSGS); Type I mesangial capillary proliferative glomerulonephritis; Refractory and/or severe lupus nephritis; Antineutrophic granulocyte cytoplasmic antibodies (ANCA) associated renal damage in small vasculitis.

For kidney patients with proteinuria, it is inevitable to use steroids or immunosuppressants for anti-inflammatory and proteinuria treatment, but some patients are dependent on steroids. Once steroids are stopped, proteinuria gets relapse, leading to a very unstable condition. Retuximab, is relatively effective in reducing the dependence of patients on hormones and is more conducive to the stability of renal function. Compared with drugs such as tacrolimus, patients have better tolerance, lower renal toxicity and more safety and efficacy.

Although it is now on the market, it is expensive and has not been widely used for the treatment of kidney patients.

Lipid-lowering, protein-lowering and kidney-protecting — Statins

Patients with high blood lipids are no strangers to statins. They can regulate blood lipids by lowering cholesterol in blood, liver and other places, and prevent cardiovascular and cerebrovascular diseases such as coronary heart disease.

So how does it function as protein-lowering medicine? Clinical studies have shown that, on the one hand, statins play a role in regulating blood lipids in the whole body, but also play a role in reducing the deposition of lipoprotein in the kidney, improving the blood circulation in the kidney and helping to reduce protein leakage. On the other hand, these drugs have the effect of inhibiting cytokines and inflammatory factors, which can help improve renal function and thus reduce proteinuria.

Commonly used statins include lovastatin, simvastatin, pravastatin, resuvastatin, fluvastatin, etc.

Blood pressure-lowering, protein-lowering and kidney-protecting — ACEI or ARBs

We've talked a lot about ACEI and ARBs, but there are some patients who don't know if they can use them. What are the side effects? Today I'd like to highlight two points:

These kidney patients can use:

Such as chronic nephritis, Nephrotic Syndrome, Purpura Nephritis, Lupus Nephritis, IgA Nephropathy, hepatitis b associated nephritis, as well as Diabetic Nephropathy and some patients with early and middle stage renal insufficiency.

Kidney patients with these symptoms or conditions should use it with caution:

-low blood pressure;

-high blood potassium;

-obvious edema;

-bilateral or unilateral renal artery stenosis;

-creatinine > 265 mol/L.

-have allergy history

Although these two kinds of drugs have the same mechanism of action, they cannot be taken at the same time, and the condition of blood potassium, blood pressure and blood creatinine should be monitored when using them. For patients with severe cough due to the use of ACEI, they can switch to ARBs. Communicate with the doctor before changing it. Do not self-medication, stop or change the medicine.

The above information is just for reference. If you still have any questions on kidney disease, please leave a message below or contact online doctor.

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